| 摘要 |
Compounds of formula (I) or a pharmaceutically acceptable salt thereofwherein R is hydrogen or Calkyl; R1 is hydrogen, Calkyl, C(O)OH, C(O)NHor (Calkylene) R10; R2 and R3 are independently hydrogen, Calkyl or R2 together with R3 and together with the carbon atom to which they are attached form a Ccycloalkyl group; R4 is Calkyl, Calkoxy or halogen; R5 and R7 are independently hydrogen, hydroxy, halogen, C(O)NH, C(O)OH or (Calkylene) R10; R6 and R8 are independently hydrogen or halogen; R9 is hydrogen, (Calkylene) R10, C(O)NH, C(O)OH or R9 together with R form a 6 membered heterocyclic ring optionally containing a further heteroatom selected from oxygen, sulphur or nitrogen; R10 is hydrogen, halogen, hydroxy, C(O)NH, C(O)NH(Calkyl), C(O)N(Calkyl)or C(O)OH; n is 0, 1 or 2; processes for their preparation, to compositions containing them and to their use in the treatment of diseases and conditions for which antagonism of NK1 is beneficial. |
