发明名称 |
KINESIN INHIBITORS AS CANCER THERAPEUTICS |
摘要 |
The invention provides novel imidazole compounds of the formulathat inhibit the activity of kinesin spindle protein (KSP, also called Eg5). Inhibitors of KSP can reduce undesired cellular proliferation and provide other therapeutic effects. The invention also provides pharmaceutical compositions containing these novel compounds, and methods of using the novel KSP inhibitors and their pharmaceutical compositions to treat various types of cancers. The compounds, compositions and methods of the invention are especially useful for treating certain classes of cancers that are resistant to conventional drug treatments, because such cancers are shown to remain sensitive to the compounds of the invention. |
申请公布号 |
EA018014(B1) |
申请公布日期 |
2013.04.30 |
申请号 |
EA20100000900 |
申请日期 |
2008.12.12 |
申请人 |
NOVARTIS AG |
发明人 |
ABRAMS TINYA;BARSANTI PAUL;DUHL DAVID;FAURE MICHEL;RENHOWE PAUL, A.;WALTER ANNETTE, OLGA |
分类号 |
A61K31/4164;A61P35/00;C07D233/00 |
主分类号 |
A61K31/4164 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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