FUSED PYRIMIDINE DERIVATIVES AS TRPV3 MODULATORS

摘要

PURPOSE: A fused pyrimidine derivative as a TRPV3 modulator is provided to treat diseases, symptoms, and/or disorders regulated by TRPV3. CONSTITUTION: A fused pyrimidine derivative as a TRPV3 modulator contains a compound of chemical formula I. In chemical formula I, ring A is aryl or heteroaryl. A heterocyclic radical is a monocyclic, bicyclic, or tricyclic system containing a fused, crosslinked, or spirocyclic system. A nitrogen, phosphorus, carbon, oxygen, or sulfur atom of the heterocyclic radical is selectively oxidized in various oxidation states.