LIPOSOME COMPRISING ELASTIN-LIKE POLYPEPTIDE AND USE THEREOF

摘要

PURPOSE: A liposome containing an elastine-like polypeptide(ELP) and a use thereof are provided to reduce the amount of drug release, and to maintain stable state. CONSTITUTION: A liposome contains: a lipid bilayer; an elastine-like polypeptide(ELP) in which hydrophobic group-containing moiety is conjugated; and a lipid bilayer stabilizing agent. The moiety is filled in the lipid bilayer. The lipid bilayer stabilizing agent is steroid which is incorporated in the lipid bilayer. The lipid bilayer stabilizing agent is selected from the group consisting of sterol or a derivative thereof, spingolipid or a derivative thereof, and a combination thereof. The lipid bilayer stabilizing agent is selected from the group consisting of cholesterol, beta-cholesterol, sistosterol, ergosterol, stigmasterol, 4,22 stigmastadiene-3-one, stigmasterol acetate, lanosterol, and a combination thereof. [Reference numerals] (AA) Calcein release(%); (BB) Cholesterol molar ratio: 25.8; (CC) Cholesterol molar ratio: 41; (DD) Temperature(°C);