| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to veterinary science and biotechnology, and concerns preparing an associated vaccines for prevention of anthrax and necrobacillosis in animals. The characterized vaccine contains the following ingredients in proportions, wt %: a suspension of living spores of the anthrax vaccine strain 55-VNIIVViM (All-Russian Research Institution of Virology and Microbiology) with the initial concentration of (5-5.2)X10in physiologic saline 1 cm- 1.0-1.2; -saponin - 1.5-2.1; -formalin-inactivated leukocidin - exotoxin with molecular weight 18-20 kDa of the strain of Fusobacterium necrophorum "0-1" VIEV (All-Russian Institution of Experimental Virology with the protein content of 5.5- 6 mg % adsorbed in 12-15% aluminium hydroxide taken in the final concentration of 1.8-2.0% pre-suspended in glycol buffer with pH 8.4-8.6 - the rest.EFFECT: preparing high-immunogenic product providing the formation of prolonged and expressed anthrax and necrobacillosis immunity.2 tbl, 3 ex |
