| 发明名称 |
METHOD OF PRODUCING 1-?-D-RIBOFURANOSYL-1,2,4-TRIAZOLE-3-CARBOXAMIDE |
| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to biotechnology. The method of producing 1--D-ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) involves reaction of excess guanosine with 1,2,4-triazole-3-carboxamide in a potassium phosphate buffer in the presence of sodium arsenate and purine nucleoside phosphorylase.EFFECT: invention enables 100% conversion of guanosine to guanine and simplifies the process of separating the end product from the reaction mixture.3 dwg, 1 tbl, 1 ex |
| 申请公布号 |
RU2480218(C1) |
申请公布日期 |
2013.04.27 |
| 申请号 |
RU20110149400 |
申请日期 |
2011.12.06 |
| 申请人 |
ROSSIJSKAJA FEDERATSIJA, OT IMENI KOTOROJ VYSTUPAET MINISTERSTVO PROMYSHLENNOSTI I TORGOVLI ROSSIJSKOJ FEDERATSII |
发明人 |
KONSTANTINOVA IRINA DMITRIEVNA;FATEEV IL'JA VLADIMIROVICH;MIROSHNIKOV ANATOLIJ IVANOVICH |
| 分类号 |
A61K31/7042;C12P19/00 |
主分类号 |
A61K31/7042 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
