B-Cell Reduction Using CD37-Specific and CD20-Specific Binding Molecules

摘要

594275 Disclosed is a humanized CD37-specific binding protein comprising: (a) human light chain framework regions, a light chain CDR1 comprising an amino acid sequence of SEQ ID NO:61, or 62, a light chain CDR2 comprising an amino acid sequence of SEQ ID NO:64, and a light chain CDR3 comprising an amino acid sequence of SEQ ID NO:66; and (b) human heavy chain framework regions, a heavy chain CDR1 comprising an amino acid sequence of SEQ ID NO:63, a heavy chain CDR2 comprising an amino acid sequence of SEQ ID NO:65, and a heavy chain CDR3 comprising an amino acid sequence of SEQ ID NO: 67 or 68.