THE GLYCOSYLATED NON-QUINONE GELDANAMYCIN DERIVATIVES HAVING INCREASED SOLUBILITY OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION FOR HEAT SHOCK PROTEIN(HSP90) ATPASE INHIBITOR CONTAINING SAME

摘要

PURPOSE: A glycosylated non-quinone geldanamycin derivative with enhanced solubility or a pharmaceutically acceptable salt thereof and a pharmaceutical composition for suppressing HSP90 ATPase activity are provided to prevent or treat cancer. CONSTITUTION: A glycosylated non-quinone geldanamycin derivative or a pharmaceutically acceptable salt thereof contains a compound of chemical formulas 1-5. The derivative enhances solubility and suppresses HSP ATPase activity. The derivative is prepared by transglycosylation using isolated glycosyltransferase and a non-quinone geldanamycin derivative. The glycosyltransferase is UDP-glycosyltransferase derived from Bacillus licheniformis.