COMPOSITIONS AND METHODS FOR PRODUCING VASCULAR OCCLUSION USING A SOLID-PHASE PLATELET BINDING AGENT

摘要

Disclosed are methods and compositions for targeting and delivering solid-phase platelet dependent vascular occlusion agents. In particular, particles or coils or stents coated with platelet binding agents are directed to target vasculature, such as the vasculature of solid tumor masses or AV-malformations or aneurysms or endoleaks; the solid-phase agent then binds and activates platelets, which in turn bind and activate other platelets. This process results in the rapid formation of a platelet-mediated thrombus about the solid-phase agent causing vessel occlusion. The agent comprises poly(lactic-coglycolic acid) microspheres coated with bovine fibrillar collagen type 1, and wherein the connective tissue replaces the biodegradable solid-phase agent as the biodegradable solid-phase agent degrades.