USE OF CDK9 INHIBITORS TO REDUCE CARTILAGE DEGRADATION
摘要
The present invention relates to the use of cyclin-dependent kinase 9 (CDK9) inhibitors to reduce, inhibit and/or prevent cartilage degradation. CDK9 inhibitors can be used to reduce, inhibit and/or prevent cartilage degradation and loss of cartilage viability during allograft storage. CDK9 inhibitors can be used as a post-injury intervention treatment to reduce, inhibit and/or prevent the acute cellular responses that lead to future cartilage degradation and osteoarthritis.
申请公布号
WO2013059634(A1)
申请公布日期
2013.04.25
申请号
WO2012US61079
申请日期
2012.10.19
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;HAUDENSCHILD, DOMINIK;DI CESARE, PAUL;YIK, JASPER;CHRISTIANSEN, BLAINE