发明名称 |
ETANERCEPT FORMULATIONS STABILIZED WITH SODIUM CHLORIDE |
摘要 |
The present invention is an aqueous etanercept formulation stabilized to reduce instability, aggregation and/or fragmentation of the etanercept, said formulation comprising about 25 to about 75 mg/ml of etanercept and one or more stabilizers, wherein the stabilizers are selected from the group consisting of sodium chloride; and sodium chloride in combination with sucrose or trehalose; and a combination of sodium chloride, sucrose and trehalose. Various technical terms used in the following discussion are defined below in the section entitled "Definitions" and throughout the remainder of the specification. The stabilized etanercept formulations of the present invention elicit long term storage stability. |
申请公布号 |
WO2013059407(A1) |
申请公布日期 |
2013.04.25 |
申请号 |
WO2012US60741 |
申请日期 |
2012.10.18 |
申请人 |
COHERUS BIOSCIENCES, INC. |
发明人 |
MANNING, MARK;MURPHY, BRIAN |
分类号 |
A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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