发明名称 |
LIPIDS CAPABLE OF CONFORMATIONAL CHANGE AND THEIR USE IN FORMULATIONS TO DELIVER THERAPEUTIC AGENTS TO CELLS |
摘要 |
The invention provides lipid-based composition for use in the administration of therapeutic payloads to target cells or tissues in vivo. The lipid compounds of the invention include a peptide-based moiety which is induced to change its conformation upon entering a cell or intracellular compartment. The induced conformation change in the peptide-based moiety consequently triggers the efficient release of the payload from the lipid-based composition. |
申请公布号 |
WO2013032643(A3) |
申请公布日期 |
2013.04.25 |
申请号 |
WO2012US49822 |
申请日期 |
2012.08.07 |
申请人 |
DICERNA PHARMACEUTICALS, INC.;BASU, SUJIT, KUMAR |
发明人 |
BASU, SUJIT, KUMAR |
分类号 |
A61K39/395;A61K9/127;A61K31/685;A61K47/30;A61K47/48;A61K48/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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