发明名称 |
SHIP INHIBITORS AND USES THEREOF |
摘要 |
The present invention relates to SHIP inhibitor compounds and methods for using these compounds. In particular, the present invention discloses the following methods: (i) a method of treating graft versus host disease in a subject; (ii) a method of inhibiting a SHIP1 protein in a cell; (iii) a method of selectively inhibiting a SHIP1 protein in a cell; (iv) a method for treating or preventing graft-versus-host disease (GVHD) in a recipient of an organ or tissue transplant; (v) a method of modulating SHIP activity in a cell expressing SHIP1 or SHIP2; (vi) a method of ex vivo or in vitro treatment of transplants; (vii) a method of inhibiting tumor growth and metastasis in a subject; (viii) a method of treating a hematologic malignancy in a subject; (ix) a method of inducing apoptosis of multiple myeloma cells; (x) a method of treating multiple myeloma in a subject; (xi) a method of inhibiting the proliferation of a human breast cancer cell; and (xii) a method of treating breast cancer in a subject.
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申请公布号 |
US2013102577(A1) |
申请公布日期 |
2013.04.25 |
申请号 |
US201113640162 |
申请日期 |
2011.04.11 |
申请人 |
KERR WILLIAM G.;CHISHOLM JOHN D.;THE RESEARCH FOUNDATION OF THE STATE UNIVERSITY OF NEW YORK |
发明人 |
KERR WILLIAM G.;CHISHOLM JOHN D. |
分类号 |
C07J41/00;C07J1/00;C07J9/00;C07J31/00 |
主分类号 |
C07J41/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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