发明名称 |
ANTI-CD22 CHIMERIC ANTIGEN RECEPTORS |
摘要 |
The disclosure provides a chimeric antigen receptor (CAR) comprising a) an antigen binding domain of HA22, a transmembrane domain, and an intracellular T cell signaling domain; or b) an antigen binding domain of BL22, a transmembrane domain, and an intracellular T cell signaling domain comprising CD28 and/or CD137. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed. |
申请公布号 |
WO2013059593(A1) |
申请公布日期 |
2013.04.25 |
申请号 |
WO2012US61025 |
申请日期 |
2012.10.19 |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
ORENTAS, RIMAS J.;MACKALL, CRYSTAL L.;PASTAN, IRA H. |
分类号 |
C07K19/00;A61K35/14;A61P35/02;C07K14/05;C07K16/28;C07K16/30;C12N5/0783 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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