发明名称 |
Receptor Tyrosine Kinase-Like Orphan Receptor 1 (ROR1) Single Chain FV Antibody Fragment Conjugates and Methods of Use Thereof |
摘要 |
Compositions including an antibody single-chain variable fragment (scFv) conjugate that specifically binds to ROR1 tumor-associated antigen are provided. The anti-ROR1 scFv antibody and conjugates may include a biologically-active molecule. Such conjugates may comprise a chimeric receptor to direct T cells to respond to ROR1 cancer cells, Methods to use the scFV conjugates to target cells expressing ROR1 for therapeutic and diagnostic purposes are also provided.
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申请公布号 |
US2013101607(A1) |
申请公布日期 |
2013.04.25 |
申请号 |
US201113703864 |
申请日期 |
2011.06.15 |
申请人 |
KIPPS THOMAS J.;YU JIANQIANG |
发明人 |
KIPPS THOMAS J.;YU JIANQIANG |
分类号 |
A61K47/48;C07K16/40;C07K16/46 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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