发明名称 |
MUC1 LIGAND TRAPS FOR USE IN TREATING CANCERS |
摘要 |
The present invention is directed to improved compositions for the disruption of signaling through the external domain (ED) of MUC1, Ligand traps-molecules that include MUC1 ED sequences and immunoglobulin Fc domains-effectively "trap" molecules that interact with the native MUC1 ED. Given the involvement of MUC1 in a variety of disease states, disrupting the interaction of other molecules with MUC1 ED is useful in treating these disease, in particular cancer.
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申请公布号 |
US2013101664(A1) |
申请公布日期 |
2013.04.25 |
申请号 |
US201213588427 |
申请日期 |
2012.08.17 |
申请人 |
KUFE DONALD W.;KHARBANDA SURENDER |
发明人 |
KUFE DONALD W.;KHARBANDA SURENDER |
分类号 |
C07K14/47;A61K39/395;A61K45/06 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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