RNAi MODULATION OF ApoB AND USE THEREOF

摘要

PROBLEM TO BE SOLVED: To provide compositions and methods for modulating the expression of apolipoprotein B, and more particularly the downregulation of apolipoprotein B by chemically modified oligonucleotides.

SOLUTION: An iRNA agent includes a sense strand having at least 15 contiguous nucleotides of the sense strand sequences, and an antisense strand having at least 15 contiguous nucleotides of the antisense sequences, of the iRNA agents provided herein under agent numbers 1-74.

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