发明名称 |
MUCIN ANTIGEN VACCINE |
摘要 |
Provided are expression vectors for generating an immune response to a mucin. The vectors comprise a transcription unit encoding a secretable polypeptide, the polypeptide comprising a secretory signal, a mucin antigen and CD40 ligand. Also provided are methods of generating an immune response against cells expressing a mucin by administering an effective amount of the vector. Further provided are methods of generating an immune response against cancer cells expressing a mucin in an individual by administering an effective amount of the vector. Still further provided are methods of overcoming anergy to a mucin self antigen by administering an effective amount of the vector.
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申请公布号 |
US2013101626(A1) |
申请公布日期 |
2013.04.25 |
申请号 |
US201213662616 |
申请日期 |
2012.10.29 |
申请人 |
MICROVAX, LLC;MICROVAX, LLC |
发明人 |
TANG YUCHENG;DEISSEROTH ALBERT |
分类号 |
A61K48/00;A61K39/00;C07K14/47;C07K14/705;C12N15/09;C12N15/62 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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