GRAINYHEAD-LIKE 1 GENE AND GRAINYHEAD-LIKE 1 TRANSCRIPTION FACTOR FOR USE IN REGULATION OF BLOOD PRESSURE IN MAMMALS

摘要

The present invention relates to diagnostic and therapeutic applications of Grainyhead-like 1 (Grhll) gene related to regulation of blood pressure in mammals. In particular, the subject of the invention is an in vitro method of diagnosis of hypo- or hypertension or a hypo- or hypertension predisposition, the medical use of agents related to Grhll gene and Grainyhead-like 1 transcription factor (GRHLl) for treatment of hypo- or hypertension, use of Grhll -/-, Grhll+/- and/or Grhll+/+ mice and a method of screening drugs against hypo- and hypertension.