| 摘要 |
The present invention provides a medicinal composition capable of preventing a decrease in the blood exposure level of a third generation coxib drug, a method for preparing the composition and utilization of the same. It was discovered that, by adding a basic amine or a basic amino acid or cyclodextrin to a third generation coxib compound, a medicinal composition capable of inhibiting a decrease in the blood concentration thereof, a decrease in the area under concentration thereof and a decrease in the bioavailability thereof can be obtained. In addition, the medicinal composition according to the present invention is highly stable and useful as a medicine. That is, a technical idea that a decrease in blood concentration, a decrease in area under concentration and a decrease in bioavailability can be inhibited by adding a basic amine or a basic amino acid or cyclodextrin is thus established. |
