发明名称 |
NOVEL VEGF MIMETIC PEPTIDE-BASED SCAFFOLDS FOR THERAPEUTIC ANGIOGENESIS AND METHODS FOR THEIR USE |
摘要 |
Disclosed herein is a completely synthetic cell-free therapy based on peptide amphiphile nanostructures designed to mimic the activity of vascular endothelial growth factor (VEGF), one of the most potent angiogenic signaling proteins. The VEGF-mimetic filaments disclosed herein were found to induce phosphorylation of VEGF receptors and induce pro-angiogenic behavior in endothelial cells, indicated by an enhancement in proliferation, survival and migration in vitro.
|
申请公布号 |
US2013101628(A1) |
申请公布日期 |
2013.04.25 |
申请号 |
US201213459234 |
申请日期 |
2012.04.29 |
申请人 |
WEBBER MATTHEW J.;TONGERS JOERN;LOSORDO DOUGLAS W.;STUPP SAMUEL I.;NORTHWESTERN UNIVERSITY |
发明人 |
WEBBER MATTHEW J.;TONGERS JOERN;LOSORDO DOUGLAS W.;STUPP SAMUEL I. |
分类号 |
C07K14/00 |
主分类号 |
C07K14/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|