发明名称 |
METHODS AND COMPOSITIONS BASED ON SHIGA TOXIN TYPE 1 PROTEIN |
摘要 |
The invention is based on the discovery of the epitope in the Stx1 protein for the 13C4 antibody. The invention features non-full length Stx1 polypeptides that include the epitope for the 13C4 monoclonal antibody epitope. The invention also features methods of producing anti-Stx1 antibodies specific for the 13C4 epitope of the Stx1 protein. Additionally, the invention features methods for treating a subject having, or at risk of developing, a Shiga toxin associated disease (e.g., hemolytic uremia syndrome and diseases associated with E. coli and S. dysenteriae infection) with a polypeptide that includes the 13C4 epitope or with an anti-Stx1 antibody developed using the methods of the invention. Furthermore, the invention features the detection of Stx1 in a sample using the antibodies developed using the methods of the invention.
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申请公布号 |
US2013101591(A1) |
申请公布日期 |
2013.04.25 |
申请号 |
US201213645928 |
申请日期 |
2012.10.05 |
申请人 |
MILITARY MEDICINE, INC. THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF;THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. |
发明人 |
SMITH MICHAEL;MELTON-CELSA ANGELA;O'BRIEN ALISON |
分类号 |
C07K16/12 |
主分类号 |
C07K16/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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