QUANTIFICATION OF ADAPTIVE IMMUNE CELL GENOMES IN A COMPLEX MIXTURE OF CELLS
摘要
<p>ABSTRACT OF THE DISCLOSURE Compositions and methods are described for highly sensitive quantification of the relative representation of DNA from adaptive immune cells (e.g., T and/or B lymphocytes) in DNA extracted from complex mixtures of cells that include cells which are not adaptive immune cells. Included are methods for determining the relative presence in a tumor of tumor infiltrating lymphocytes (TIL), the relative presence of lymphocytes infiltrating a somatic tissue that is the target of an autoimmune disease, and the relative presence of lymphocytes infiltrating a transplanted organ.</p>
申请公布号
WO2013059725(A1)
申请公布日期
2013.04.25
申请号
WO2012US61193
申请日期
2012.10.19
申请人
ADAPTIVE BIOTECHNOLOGIES CORPORATION;FRED HUTCHINSON CANCER RESEARCH CENTER
发明人
ROBINS, HARLAN, S.;LIVINGSTON, ROBERT, J.;BIELAS, JASON, H.