| 摘要 |
The main object of the present invention is to provide a method for removing a 2-cyanoethoxymethyl (CEM) group, which substitutes the 2'-hydroxyl group of each ribose of an oligonucleic acid derivative, with good reproducibility and high efficiency. The object is to provide a method for producing an oligonucleic acid derivative represented by the following general formula (11), characterized by using a sulfoxide-based solvent or an amide-based solvent or a mixture thereofas a reaction solvent in the step of removing a protecting group, which protects the 2'-hydroxyl group of each ribose of an oligonucleic acid derivative represented by the following general formula (10) by allowing TBAF to act on the oligonucleic acid derivative. |
