发明名称 |
CYCLOHEXYL-AZETIDINYL ANTAGONISTS OF CCR2 |
摘要 |
<p>The present invention comprises compounds of Formula I. wherein: R1, R2, R4, J, Q, and A are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.</p> |
申请公布号 |
EP2582692(A1) |
申请公布日期 |
2013.04.24 |
申请号 |
EP20110729234 |
申请日期 |
2011.06.16 |
申请人 |
JANSSEN PHARMACEUTICA, N.V. |
发明人 |
LANTER, JAMES, C.;MARKOTAN, THOMAS, P.;SUBASINGHE, NALIN;SUI, ZHIHUA |
分类号 |
C07D401/12;A61K31/4375;A61K31/4709;A61K31/502;A61K31/517;A61P29/00;C07D401/14;C07D403/12;C07D403/14;C07D405/14;C07D413/14;C07D417/14;C07D471/04 |
主分类号 |
C07D401/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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