IMPROVED PROCESS FOR PREPARATION OF CLOPIODOGREL BISULFATE CRYSTALLINE FORM-1
摘要
<p>An improved process for preparing crystalline form-1 of (S)-methyl 2-(2-chlorophenyl)-2-{6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl}acetate bisulfate (clopidogrel bisulfate) of formula I is provided The preparation comprises the straight conversion of an uncyclized material of (S)-methyl 2-[2-(thiophen-2-yl)ethylamino]-2-(2-chlorophenyl) acetate hydrochloride into clopidogrel bisulfate crystalline form-1 without any degradation of clopidogrel base</p>
申请公布号
EP2491044(A4)
申请公布日期
2013.04.24
申请号
EP20100828022
申请日期
2010.03.22
申请人
PHARMAZELL GMBH;BURGER, WOLFGANG;GUDAPARTHI, OMPRAKASH;REDDY, KONDA SRINIVASA;KUMAR, SUNEEL K.;RAMANA, VENKATA P.
发明人
BURGER, WOLFGANG;GUDAPARTHI, OMPRAKASH;REDDY, KONDA SRINIVASA;KUMAR, SUNEEL, K.;RAMANA, VENKATA, P.