发明名称 |
LIPOSOME ALLOWING THE DISCHARGE OF SUBSTANCE ENTRAPPED THEREIN FROM ENDOSOME |
摘要 |
With the aim of providing a liposome, having a hydrophilic polymer introduced into the outer surface of the liposome membrane, which is a liposome capable of allowing the liposome-entrapped substance to escape from the endosome and be released into the cytoplasm, a liposome membrane component bound to the peptide shown by (a) or (b) below and a liposome membrane component bound to one end of a hydrophilic polymer the other end of which is bound to the peptide shown by (a) or (b) below are included in the liposome: (a) a peptide comprising the amino acid sequence of SEQ ID N0:1; (b) a peptide comprising the amino acid sequence of SEQ ID NO:1 with 1 or more amino acids deleted, replaced or added therein, and capable of fusing lipid membranes with one another under acidic conditions. |
申请公布号 |
EP1832280(B1) |
申请公布日期 |
2013.04.24 |
申请号 |
EP20050759962 |
申请日期 |
2005.07.12 |
申请人 |
JAPAN SCIENCE AND TECHNOLOGY AGENCY |
发明人 |
KOGURE, KENTARO;FUTAKI, SHIROH;HARASHIMA, HIDEYOSHI |
分类号 |
A61K9/127;A61K47/34;A61K47/42 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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