REAGENTS AND METHODS FOR ENGAGING UNIQUE CLONOTYPIC LYMPHOCYTE RECEPTORS

摘要

Platforms comprising at least one lymphocyte affecting molecule and at least
one molecular complex that, when bound to an antigen, engages a unique
clonotype lymphocyte receptor can be used to induce and expand therapeutically
useful numbers of specific lymphocyte populations. Antigen presenting
platforms comprising a T cell affecting molecule and an antigen presenting
complex can induce and expand antigen-specific T cells in the presence of
relevant peptides, providing reproducible and economical methods for
generating therapeutic numbers of such cells. Antibody inducing platforms
comprising a B cell affecting molecule and a molecular complex that engages
MHC-antigen complexes on a B cell surface can be used to induce and expand B
cells that produce antibodies with particular specificities.