发明名称 |
Method for conducting an assay for neutralizing antibodies |
摘要 |
A method for conducting a neutralization assay for the determination of the titer of antibodies in a sample is provided which is an improvement over existing neutralization assays because the sensitivity of the reporter gene assay to determine neutralization is increased by the use of a "one time use" cell line transformed with a reporter gene construct. The titer is determined for antibodies specific for a predetermined target molecule that activates the signal transduction activity of a cell surface protein or a pattern recognition receptor or are specific for an antagonist for the predetermined target molecule. |
申请公布号 |
US8426123(B2) |
申请公布日期 |
2013.04.23 |
申请号 |
US20080260871 |
申请日期 |
2008.10.29 |
申请人 |
TOVEY MICHAEL G.;LALLEMAND CHRISTOPHE;BIOMONITOR LIMITED;LE CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE |
发明人 |
TOVEY MICHAEL G.;LALLEMAND CHRISTOPHE |
分类号 |
C12Q1/00 |
主分类号 |
C12Q1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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