QUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF

摘要

This invention relates to new quinolone based compounds of Formula I
(see formula I)

that exhibit prolyl hydroxylase inhibitory activity. This invention also
relates to methods of
increasing HIF levels or activity in a subject or treating a condition
associated with HIP levels or
activity in a subject by administering to the subject at least one quinolone
based compound. This
invention further involves assays for the detection of a hydroxyproline
residue in a HIF molecule.