发明名称 |
Oligomeric compounds comprising tricyclic nucelosides and methods for their use |
摘要 |
The present disclosure provides tricyclic nucleosides, oligomeric compounds comprising at least one of the tricyclic nucleosides and methods of using the oligomeric compounds. The methods provided herein include contacting a cell or administering to an animal at least one of the oligomeric compounds. In certain embodiments, the oligomeric compounds hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
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申请公布号 |
US8426378(B2) |
申请公布日期 |
2013.04.23 |
申请号 |
US20090922832 |
申请日期 |
2009.03.19 |
申请人 |
SWAYZE ERIC E.;SIWKOWSKI ANDREW M.;SETH PUNIT P.;PRAKASH THAZHA P.;ISIS PHARMACEUTICALS, INC. |
发明人 |
SWAYZE ERIC E.;SIWKOWSKI ANDREW M.;SETH PUNIT P.;PRAKASH THAZHA P. |
分类号 |
C12N15/11;C07H21/04;C12Q1/68 |
主分类号 |
C12N15/11 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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