| 发明名称 |
Alpha 1-3 N-galactosyltransferase with altered donor specificities |
| 摘要 |
The invention generally features compositions and methods based on the structure-based design of alpha 1-3 N-Acetylgalactosaminyltransferase (alpha 3 GaINAc-T) enzymes from alpha 1-3 galactosyltransferase (a3Gal-T) that can transfer 2'-modified galactose from the corresponding UDP-derivatives due to substitutions that broaden the alpha 3Gal-T donor specificity and make the enzyme a3 GaINAc-T.
|
| 申请公布号 |
US8425901(B2) |
申请公布日期 |
2013.04.23 |
| 申请号 |
US20100674638 |
申请日期 |
2010.02.22 |
| 申请人 |
QASBA PRADMAN K.;RAMAKRISHNAN BOOPATHY;BOEGGEMAN ELIZABETH;PASEK MARTA;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
QASBA PRADMAN K.;RAMAKRISHNAN BOOPATHY;BOEGGEMAN ELIZABETH;PASEK MARTA |
| 分类号 |
A61K38/46;C07H21/04;C12N9/00 |
主分类号 |
A61K38/46 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
