发明名称 |
2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (BACE) |
摘要 |
The present invention is directed to novel 2-amino-3,4-dihydro-quinazoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of beta-secretase, also known as beta-site cleaving enzyme and BACE. |
申请公布号 |
US8426429(B2) |
申请公布日期 |
2013.04.23 |
申请号 |
US20050197608 |
申请日期 |
2005.08.04 |
申请人 |
BAXTER ELLEN;BOYD ROBERT;COATS STEVEN J.;JORDAN ALFONZO D.;REITZ ALLEN B.;REYNOLDS CHARLES H.;SCHULZ MARK;SCOTT MALCOLM;JANSSSEN PHARMACEUTICA N.V. |
发明人 |
BAXTER ELLEN;BOYD ROBERT;COATS STEVEN J.;JORDAN ALFONZO D.;REITZ ALLEN B.;REYNOLDS CHARLES H.;SCHULZ MARK;SCOTT MALCOLM |
分类号 |
A61K31/517;A61K31/535;C07D239/88;C07D239/94;C07D265/30;C07D401/06 |
主分类号 |
A61K31/517 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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