MODIFIED POLY(ETHYLENE OXIDE-AMINO ACID) COPOLYMER, MICELLE PREPARATION, AND ANTICANCER AGENT CONTAINING THE SAME

摘要

Provided are: a modified poly(ethylene oxide-amino acid) block copolymer obtained by reacting a compound of formula (1): (see formula 1) with a carbodiimide compound in a solvent at 30 to 60°C for 2 to 48 hours; a micelle preparation formed from the block copolymer and a sparingly water-soluble anticancer agent; and an anticancer agent comprising the micelle preparation as an active ingredient. The block copolymer can be a drug carrier having no harmful side effects such as hypersensitive reaction; the micelle preparation can heighten the solubility of the drug in water; and the anticancer agent maintains a high concentration in the blood, has more potent drug activity, and is reduced in toxicity.