17,20(E)-DEHYDRO VITAMIN D ANALOGS AND THEIR USES

摘要

This invention discloses 17,20(E)-dehydro-vitamin D analogs, and specifically 17(E)-1.alpha.,25-dihydroxy-17(20)-dehydro-2-methylene-19-nor-vitamin D3 and pharmaceutical uses therefor. This compound has use as an anti-cancer agent, in the treatment of skin diseases and skin conditions and in the treatment of autoimmune disorders and inflammatory diseases as well as renal osteodystrophy and obesity. The compounds have the formula I: (see formula I) where Y1 and Y2 are each hydrogen or a hydroxy protecting group, where R11 and R12 are each hydrogen, where R6 and R7 are hydrogen, alkyl, hydroxyalkyl, fluoroalkyl, hydroxy or alkoxy, or R6 and R7 when taken together may represent the group -(CH2)x-where x is an integer from 2 to 5, or R6 and R7 when taken together may represent the group =CR8R9 where R8 and R9 are hydrogen, alkyl, hydroxyalkyl, fluoroalkyl, hydroxy or alkoxy, or when taken together R8 and R9 may represent the group -(CH2)x- where x is an integer from 2 to 5, and where the group R represents typical side chains known for vitamin D type compounds.