发明名称 |
ISOTOPE PRODUCTION METHOD |
摘要 |
The present invention relates to a method for the generation of 223Ra of pharmaceutically tolerable purity comprising: i) preparing a generator mixture comprising 227Ac, 227Th and 223Ra in a first aqueous solution comprising a first mineral acid; ii) loading said generator mixture onto a DGA separation medium (e.g. resin); iii) eluting said 223Ra from said DGA separation medium using a second mineral acid in a second aqueous solution to give an eluted 223Ra solution; and iv) stripping the DGA separation medium of said 227Ac and 227Th by flowing a third mineral acid in a third aqueous solution through the DGA separation medium in a reversed direction; The invention further relates to high purity radium-223 formed or formable by such a method as well as pharmaceutical compositions comprising such radium-223 of pharmaceutical purity.
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申请公布号 |
US2013095031(A1) |
申请公布日期 |
2013.04.18 |
申请号 |
US201113695355 |
申请日期 |
2011.04.29 |
申请人 |
KARLSON JAN ROGER;BOERRETZEN PEER;ALGETA ASA |
发明人 |
KARLSON JAN ROGER;BOERRETZEN PEER |
分类号 |
A61K51/00 |
主分类号 |
A61K51/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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