发明名称 |
New binder-drug conjugates (ADCs) and use thereof |
摘要 |
The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target C4.4a, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures.
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申请公布号 |
US2013095123(A1) |
申请公布日期 |
2013.04.18 |
申请号 |
US201213656681 |
申请日期 |
2012.10.20 |
申请人 |
BAYER PHARMA AG;BAYER INTELLECTUAL PROPERTY GMBH;SEATTLE GENETICS, INC.;SEATTLE GENETICS, INC.;BAYER INTELLECTUAL PROPERTY GMBH |
发明人 |
LERCHEN HANS-GEORG;LINDEN LARS;EL SHEIKH SHERIF;WILLUDA WILLUDA;KOPITZ CHARLOTTE CHRISTINE;SCHUHMACHER JOACHIM;GREVEN SIMONE;MAHLERT CHRISTOPH;STELTE-LUDWIG BEATRIX;GOLFIER SVEN;BEIER RUDOLF;HEISLER IRING;HARRENGA AXEL;THIERAUCH KARL-HEINZ;BRUDER SANDRA;PETRUL HEIKE;JOERISEN HANNAH;BORKOWSKI SANDRA |
分类号 |
C07K16/30;A61K45/06;A61K47/48;C07K7/02 |
主分类号 |
C07K16/30 |
代理机构 |
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代理人 |
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地址 |
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