| 摘要 |
<p>L-b -, D-a - and D-b -Asparagyl-L-a -amino-(amino lower alkyl)-acetyl-L-a -amino lower alkyl - acetyl - L - tyrosyl - L - a - amino - lower alkyl - acetyl - L - histidyl - L - prolyl - L - phenylalanine and its physiologically tolerable acid addition salts are prepared by linking an appropriately substituted L- or D-aspartic acid in the given order of succession with the amino acids: L-a -amino-(amino-lower alkyl)-acetic acid, L-a -amino-lower alkyl acetic acid, L-tyresine, L-a -amino-lower alkyl acetic acid, L-histidine, L-proline, L-phenylalanine by a series of reactions selected from condensations of amino acids with further amino acids, condensations of amino acids with smaller peptide chains and condensation of smaller peptide chains with further smaller peptide chains in which amino groups or carboxylic groups not taking part in the reactions are protected and removing the protecting groups at the end of the synthesis. "Lower alkyl" is defined as a C1- 4 alkyl group. Nitro - arg - val - tyr - val - bis - pro - phe - OMe is prepared from its carbobenzoxy derivative. Pharmaceutical compositions having hypertensive action comprise the compounds of the invention and a carrier therefore. The compositions are in forms suitable for enteral or parenteral administration.</p> |
