发明名称 |
LYSINE DEMETHYLASE INHIBITORS FOR DISEASES AND DISORDERS ASSOCIATED WITH HEPADNAVIRIDAE |
摘要 |
The present invention provides for the treatment or prevention of Hepadnaviridae infection and disease caused by Hepadnaviridae infection. In particular, the invention provides compositions and methods that affect the ability of Hepadnaviridae to utilize the host's cellular machinery as part of the virus' lifecycle. The invention relates to the discovery that interfering with the normal ability of viruses to utilize the host cell machinery with LSD1 inhibitors reduces HBV replication. Thus, the treatment and prevention of Hepadnaviridae infection and disease caused by Hepadnaviridae according to the invention comprises administering to an individual in need of treatment, a therapeutically effective amount of a LSD1 inhibitor. The individual in need of treatment can be a human or, e.g., another mammal. |
申请公布号 |
US2013095067(A1) |
申请公布日期 |
2013.04.18 |
申请号 |
US201113580710 |
申请日期 |
2011.02.24 |
申请人 |
BAKER JONATHAN ALLEMAN;FYFE MATTHEW COLIN THOR |
发明人 |
BAKER JONATHAN ALLEMAN;FYFE MATTHEW COLIN THOR |
分类号 |
A61K31/135;A61K31/131;A61K31/137;A61K31/165;A61K38/21;A61K45/06 |
主分类号 |
A61K31/135 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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