发明名称 |
Compounds Useful as Inhibitors of ATR Kinase |
摘要 |
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.
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申请公布号 |
US2013096139(A1) |
申请公布日期 |
2013.04.18 |
申请号 |
US201213631727 |
申请日期 |
2012.09.28 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED;VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
CHARRIER JEAN-DAMIEN;STORCK PIERRE-HENRI;STUDLEY JOHN;PIERARD FRANCOISE YVONNE THEODORA MARIE |
分类号 |
A61K45/06;A61K31/497;C07D413/14 |
主分类号 |
A61K45/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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