ANTIBODY-BINDING PEPTIDE-FERRITIN FUSION PROTEIN AND USES THEREOF

摘要

The present invention relates to nanoparticles including 24 antibody-binding peptide-ferritin fusion protein monomers, the nanoparticles being characterized in that six partial structures having a 4-fold symmetry point are formed due to ferritin, and an antibody-binding peptide is fused to the ferritin in a range of ±10 a.a. of the 4-fold symmetry point such that 4 antibody-binding peptides are positioned in the vicinity of the 4-fold symmetry point; and also relates to uses of the nanoparticles. The present invention can be used for biochips, drug delivery systems, disorder diagnosis, and the development of treating agents by producing the fusion protein through the introduction of the sequence of the antibody-binding peptide into the ferritin, and using the fusion protein to allow the antibody to strongly bind to the ferritin without any damage to the antibody structure.