发明名称 |
MOLECULES WHICH BIND CLEC9A |
摘要 |
The present invention relates to the identification of molecules which bind the dendritic cell marker known as Clec9A. The present invention provides new compounds for targeting therapeutic agents such as antigens to dendritic cells. Also provided are methods of modulating a humoral and/or T-cell mediated immune response to the antigen, methods of delivery of a cytotoxic agent to dendritic cells thereof involved in diseased states, methods of modulating the uptake and/or clearance of cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof, and methods of modulating antigen recognition, processing and/or presentation, as well as immune responses to material derived from cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof. |
申请公布号 |
WO2013053008(A2) |
申请公布日期 |
2013.04.18 |
申请号 |
WO2012AU01233 |
申请日期 |
2012.10.12 |
申请人 |
THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH |
发明人 |
COLMAN, PETER MALCOLM;COPPEL, ROSS LEON;CZABOTAR, PETER EDWARD;LAHOUD, MIREILLE HANNA;NICOLA, NICOS ANTHONY;POLICHENI, ANTONIA NATALIE;SHORTMAN, KENNETH DOUGLAS;TULLETT, KIRSTEEN MCINNES;ZHANG, JIAN-GUO;BAUM, JACOB;WONG, WILSON |
分类号 |
C07K19/00 |
主分类号 |
C07K19/00 |
代理机构 |
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