发明名称 |
Model and Methods for Identifying Points of Action in Electrically Active Cells |
摘要 |
The invention provides a model for generating predicted action potentials of an electrically active cell. The disclosed model includes three operatively coupled submodels. A first submodel contains Hodgkin-Huxley elements generating action potentials based on electrical equivalent circuits. A second submodel is based on reaction kinetics of cell metabolism and is operatively coupled with the first submodel. A third submodel is based on Boolean dynamics representing signaling and associated cellular processes and is operatively coupled with the first and second submodels. The invention includes storing a library of calculated action potentials and associated cellular parameters generated by the model, applying a stimulus to the electrically active cell in vitro so that the cell generates an action potential; and comparing the cell-generated action potential with those stored in the library, wherein a match is predictive of the cellular point of action of the applied stimulus according to the parameters stored.
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申请公布号 |
US2013096888(A1) |
申请公布日期 |
2013.04.18 |
申请号 |
US201113576442 |
申请日期 |
2011.02.07 |
申请人 |
HICKMAN JAMES;MOLNAR PETER;SOMMERHAGE FRANK;HOOD JONATHAN;JENKINS JERRY;UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. |
发明人 |
HICKMAN JAMES;MOLNAR PETER;SOMMERHAGE FRANK;HOOD JONATHAN;JENKINS JERRY |
分类号 |
G06F17/50 |
主分类号 |
G06F17/50 |
代理机构 |
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代理人 |
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地址 |
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