发明名称 |
ANTI-ILT7 ANTIBODY |
摘要 |
An antibody binding to IPC was obtained by using an animal cell in which a cell membrane protein associatable with ILT7 was co-expressed as an immunogen. The antibody of the invention has a high specificity which allows immunological distinction between other ILT family molecules and ILT7. The anti-ILT7 antibody of the invention bound to IPC and inhibited the activity thereof. With the anti-ILT7 antibody of the invention, the IPC activity can be inhibited and an interferon-related disease can be treated or prevented. ILT7 expression is maintained even in IPC in the presence of IFN±. Therefore, an inhibitory action of IPC activity by the anti-ILT7 antibody can be expected even in an autoimmune disease patient with an increased production of IFN±. |
申请公布号 |
EP1964852(B1) |
申请公布日期 |
2013.04.17 |
申请号 |
EP20060842945 |
申请日期 |
2006.12.20 |
申请人 |
SBI BIOTECH CO., LTD. |
发明人 |
KAMOGAWA, YUMIKO;CHO, MINKWON;ARAI, NAOKO;ISHIDA, KOJI |
分类号 |
C07K16/28;A61K39/395;A61K48/00;A61P17/06;A61P31/18;A61P35/00;A61P37/02;A61P43/00;C12N5/10;C12N15/09;C12P21/08;G01N33/53;G01N33/566;G01N33/577;G01N33/68 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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