| 摘要 |
<p>The invention comprises sulphonyl ureas of he formula <FORM:0974989/C1/1> in which R1 represents a cycloalkyl radica having 5 to 8 carbon atoms which may contain one or more double bonds or may be substituted by one or more alkyl groups. Numerous methods of preparation of these compounds are given, most of which are based on the reaction between a compound of formula <FORM:0974989/C1/2> with a compound of formula Y-R1. In these formula X and Y represent two radicals which in the course of the reaction together form a urea linkage. Examples of X and Y are: amino and isocyanate; carbamic acid ester and amino; amino and carbamic acid chloride; substituted or unsubstituted urea and amino. The corresponding thiourea compound may be prepared and then the sulphur atom replaced by oxygen. If desired the hydroxy groups may be protected during the preparation, the protecting group being removed, e.g. by hydrolysis to yield the desired product. Numerous examples are given. The above compounds have a necotropic liner protective action and are used in conjunction with a pharmaceutically suitable carrier for this purpose, either as the pure compound or as a physiologically tolerable salt thereof. They are suitable for oral or parental administration and are used in dosage form, each dose containing 50 to 500 m.g. of the sulphonyl urea or salt thereof. The salt may be with an inorganic or organic base.</p> |
