| 摘要 |
A method has been developed of preventing or limiting formation of adhesions by administering to a site in need thereof, in the absence of or after bleeding or leakage of fluid has been substantially stopped, a self-assembling material which forms a barrier to formation of adhesions. In one embodiment, the self-assembling material comprises peptides having a sequence of amino acid residues conforming to one or more of Formulas I-IV:
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ ((Xaa neu -Xaa + ) x Xaa neu -Xaa - ) y ) n €ƒ€ƒ€ƒ€ƒ€ƒ(I)
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ ((Xaa neu -Xaa - ) x (Xaa neu -Xaa + ) y ) n €ƒ€ƒ€ƒ€ƒ€ƒ(II)
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ ((Xaa + -Xaa neu ) x (Xaa - -Xaa neu ) y ) n €ƒ€ƒ€ƒ€ƒ€ƒ(III)
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ ((Xaa - -Xaa neu ) x (Xaa +- Xaa neu ) y ) n €ƒ€ƒ€ƒ€ƒ€ƒ(IV),
where Xaa neu represents an amino acid residue having a neutral charge; Xaa + represents an amino acid residue having a positive charge; Xaa - represents an amino acid residue having a negative charge; x and y are integers having a value of 1, 2, 3 or 4, independently; and n is an integer having a value of 1-5. In another embodiment, the self assembling materials are peptidomimetics, nucleotidomimetics, di- and triblock copolymers, N-alkylacrylamides, or dendimers. These materials are also useful in a method for regeneration or repair of tissue or cells forming tissue. |
