SUBSTITUTED QUINOLONES III

摘要

The invention relates to substituted quinolones of formula
(see formula I)



in which R1 represents hydrogen, fluorine, chlorine or trifluoromethyl, R3
represents halogen, hydroxy,

C1-C4-alkoxy, cyano, trifluoromethyl, monofluoromethoxy, difluoromethoxy,
trifluoromethoxy or ethynyl,

R4represents C1-C6-alkyl or C3-C8-cycloalkyl, whereby alkyl can be substituted
with 1 to 3 substituents,

whereby the substituents are selected independently of one another from the
group consisting of halogen,

hydroxy, amino, cyano, trifluoromethyl, hydroxycarbonyl, aminocarbonyl, C1-C6-
alkoxy, C1-C6-alkylamino, C1-

C6-alkylcarbonyl and C1-C6-alkoxycarbonyl,and whereby cycloalkyl can be
substituted with 1 to 3 substituents,

whereby the substituents are selected independently of one another from the
group consisting of halogen,

hydroxy, amino, cyano, trifluoromethyl, hydroxycarbonyl, aminocarbonyl, C1-C6-
alkyl, C1-C6-alkoxy, C1-C6-

alkylamino, C1-C6-alkylcarbonyl and C1-C6-alkoxycarbonyl, or R3 and R4,
together with the atoms to which they

are attached, form a ring through a group of formula
(see formula II)



whereby * is the linkage site to the carbon atom, and # is the linkage site to
the nitrogen atom, R7 and R8

independently of one another represent halogen, hydroxy, cyano,
trifluoromethyl, monofluoromethoxy,

difluoromethoxy, trifluoromethoxy, C1-C3-alkyl or C1-C3-alkoxy, and R9
represents hydrogen, halogen,

hydroxy, cyano, trifluoromethyl, monofluoromethoxy, difluoromethoxy,
trifluoromethoxy, C1-C3-alkyl or C1-



formula
(see formula III)
C3-alkoxy, or R8 represents trifluoromethoxy, and R7 and R9 represent
hydrogen, R10 represents a group of



whereby * is the linkage site to the carbon atom, R2 is attached at position 3
or 4 and represents hydroxy,

hydroxycarbonyl, aminocarbonyl, C1-C4-alkyl, C1-C4-alkoxycarbonyl, C3-C6-
cycloalkylaminocarbonyl or

optionally hydroxy-substituted C1-C6-alkylaminocarbonyl, whereby alkyl is
substituted with a substituent,

whereby the substituent is selected from the group consisting of hydroxy,
hydroxycarbonyl, aminocarbonyl, C1-

C4-alkoxycarbonyl and 2-oxopyrrolidin-l-yl, R5 and R6 independently of one
another are attached at position 3,

4 or 5 and independently of one another represent hydrogen, hydroxy, methyl,
or ethyl, and Y represents a

methylene group or an oxygen atom, or one of its salts, its solvates or the
solvates of its salts.