发明名称 |
Amine functionalized superparamagnetic nanoparticles for the synthesis of bioconjugates and uses therefor |
摘要 |
Amine functionalized magnetic nanoparticle compositions and processes for synthesizing the same are described. The process consists of obtaining a carboxylated polymer in substantially pure form, which is used to prepare a substantially size homogeneous, polymer coated carboxyl, functionalized magnetic nanoparticle. The carboxyl groups are converted to reactive primary amino groups by the use of a water-soluble carbodiimide followed by reaction of a large excess of a diamine. The amine-terminated nanoparticles are then reacted with bifunctional crosslinking agents and with various biomolecules to make nanoparticles for in vitro assays, cell sorting applications and target specific MR contrast agents. |
申请公布号 |
US8420055(B2) |
申请公布日期 |
2013.04.16 |
申请号 |
US20080118020 |
申请日期 |
2008.05.09 |
申请人 |
GAW DEBRA A.;JOSEPHSON LEE;VISEN MEDICAL, INC. |
发明人 |
GAW DEBRA A.;JOSEPHSON LEE |
分类号 |
A61K49/18;A61K9/50;A61K47/48 |
主分类号 |
A61K49/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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