TREATMENT OF INFLAMMATORY BOWEL DISEASE

摘要

This invention relates to methods of treatment of inflammatory bowel disease,
and especially to treatment of this condition with cyclic peptidic and
peptidomimetic compounds which have the ability to modulate the activity of G
protein-coupled receptors. The compounds preferably act as antagonists of the
C5a receptor, and are active against C5a receptors on polymorphonuclear
leukocytes and macrophages. Particularly preferred compounds for use in the
methods of the invention are disclosed.