11&bgr;hydroxysteroid dehydrogenase type 1

摘要

The invention provides gene-targeted non-human animals comprising a genetically modified 11&bgr;HSD1 gene encodes a mutant 11&bgr;HSD1 polypeptide which is modulated by human 11&bgr;HSD1 modulating compounds. The invention further provides cells expressing mutant 11&bgr;HSD1 and cells isolated from gene-targeted animals, which cells produce a mutant 11&bgr;HSD1. The invention further provides methods of identifying agents that modulate 11&bgr;HSD1 activity, and are useful to treat 11&bgr;HSD1-related metabolic disorders.